Herbs like Ashwagandha are known to interact with SSRI and other medicines. Bull Natl Res Cent. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. As a general rule of thumb, never exceed the recommended dose of ashwagandha. View abstract. Doses higher than that may interact with lexapro, or produce more pronounced effects. Take extra care if you are at a high risk for infection. J Ethnopharmacol 1991;33:91-5. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Medicine (Baltimore). Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. View abstract. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Monitor your blood pressure closely. People taking certain medications may need to avoid using ashwagandha. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. View abstract. Sud Khyati S, Thaker B. Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. Ashwagandha interacts with 623 drugs. Taking it with drugs that increase levels of thyroid hormone (e.g. In rare cases, the use of ashwagandha may lead to liver damage. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Acta Pol.Pharm. At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. Pharmacol Biochem.Behav 2003;75(3):547-555. Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. Its effect on arterial blood pressure in anaesthetized dogs. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. J Med Food 2022. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Ashwagandha: MedlinePlus Supplements 1996;35(1):95-100. This product may interfere with some lab tests. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Does Ambien Cause Withdrawal Symptoms After Stopping? Hydroxyzine: Generic, Uses, Side Effects, Dosages - RxList Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. Guerrero FA, Medina GM. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. 2012;10(1):48-49. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. Select a condition to view a list of vitamins. 1965;9(1):9-15. Ashwagandha, also known as 'Indian Ginseng' is an evergreen shrub indigenous to India, the Middle East, and some parts of Africa. J Clin Med 2021;10(16):3644. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. National Center for Complementary and Integrative Health. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. The effect of standardized ashwagandha extract (35% withanolide glycosides) on fatigue, vitality and associated steroid hormonal systems in healthy aging, overweight men (40 to 70 years of age; BMI, 25 to 35) was investigated via a 16-week, double-blind, randomized, placebo-controlled crossover trial (N=57). Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. What are some herbs that are contraindicated with Cotellic (cobimetinib)? Ashwagandha has no known moderate interactions with any drugs. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. You should also review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. 1992;30(3):169-172. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970, Tiwari S, Gupta SK, Pathak AK. We comply with the HONcode standard for trustworthy health information. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Cent.Nerv.Syst.Agents Med.Chem. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. If you are experiencing serious medical symptoms, please see the There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. You can also use ashwagandha as an herbal tea. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. 2021;16(9):e0257843. This information may not fit your specific health circumstances. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. Staff. Yakugaku Zasshi 2008;128(8):1159-1167. 2020;72:28-36. View abstract. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. Some of the more compelling potential uses of ashwagandha are outlined below. J Ethnopharmacol. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Ashwaganda is used to treat Herbal Supplementation. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. 2013;45(4):417-8. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Are there any side effects of ashwagandha? View abstract. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Adaptogenic Herbs And Their Interaction With Medications - Thyroid Nation Does Ashwagandha interact with other medications? Find - Forest Raga Read More. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Ashwagandha Uses, Benefits & Side Effects - Drugs.com In general, Ashwagandha is thought to be safe when used in moderate amounts. Chauhan S, Srivastava MK, Pathak AK. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. Skinmed. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Often, herbs and supplements come with a risk of side effects. Ashwagandha may be used for anxiety due to its perceived anti-inflammatory and antioxidant properties. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020.